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Kinase inhibitor C1
CAS No. 133712-17-1
Kinase inhibitor C1( —— )
Catalog No. M11347 CAS No. 133712-17-1
A potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameKinase inhibitor C1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM.
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DescriptionA potent small molecule inhibitor of MELK kinase activity with IC50 of 42 nM; causes mitotic arrest and subsequent cellular apoptosis in vitro; strongly induces tumor cell apoptosis in slice cultures of GBM surgical specimens and attenuates growth of mouse intracranial tumors derived from GSCs; also inhibits Aurora A/B/C (IC50=61/31/124 nM), and Chk1 (IC50=262 nM); a multi-kinase inhibitor.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetMELK
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RecptorMELK
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Research Area——
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Indication——
Chemical Information
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CAS Number133712-17-1
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Formula Weight292.338
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Molecular FormulaC18H16N2O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name8-ethyl-3-methoxy-7,10-dihydro-11H-benzo[e]pyrido[4,3-b]indol-11-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Minata M, et al. PLoS One. 2014 Apr 16;9(4):e92546.
2. Hoang TM, et al. Cell Cycle. 2009 Mar 1;8(5):765-72.
molnova catalog
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